Antiemetic Palonosetron ไฮโดรคลอไรด์ Cas 135729-62-3

Good Quality Palonosetron Hydrochloride CAS 135729-62-3 as Antiemetic

Product Name: Palonosetron Hydrochloride
Synonyms: (S)-2-((S)-quinuclidin-3-yl)-2,3,3a,4,5;Palonosetron hydrochloride, 99.5%, a 5-HT3 antagonist;PALONOSETRON HCL;PALONOSETRON HYDROCHLORIDE;CS-292;Palonosetronhydrochloride hydrochloride;Palonosetron-d3 HCl;(3aS)-2-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one Hydrochloride
CAS: 135729-62-3
MF: C19H25ClN2O
MW: 332.87
EINECS: 680-630-6
Melting point: >290°C
Storage temp.: Refrigerator

Description:

Palonosetron hydrochloride is a drug to inhibit nausea and vomiting, which is a new type highly selective, high-affinity 5-HT3 receptor antagonist that can block the vomiting reflex center peripheral neurons presynaptic 5-HT. Receptor excitement directly affects the central nervous system in 5-HT. Impulse receptor excitement generated by the role of vagal afferent nerve after area, blocking the vagus nerve endings in the gut, preventing signals to 5-HT. Receptor trigger zone can reduce the incidence of nausea and vomiting. Central clinically for the treatment of acute severe emetogenic chemotherapy induced delayed nausea and vomiting. Because of its high curative effect, little side effect, long half-life (about 40 h), small dosage, and so on, it has attracted much attention.

Usage:

Serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.

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